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KMID : 1145520180040020106
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Journal of Radiopharmaceuticals and Molecular Probes
2018 Volume.4 No. 2 p.106 ~ p.114
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The radioligands with VEGF121 for angiogenesis of tumor
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Yim Min-Su
Ryu Eun-Kyoung
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Abstract
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Angiogenesis is the new blood vessel formation process and has known to a fundamental event of tumor growth and metastasis. Especially, vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFRs) are the crucial regulators of angiogenesis in tumor. VEGF-A is one of the VEGF family and binds to endothelial cell specific VEGFR1 and VEGFR2, which are associated with tumor growth and tumor angiogenesis. VEGF121 is more tumorigenic isomer of VEGF-A. Targeted VEGF or VEGFR molecular imaging has been widely used to enable diagnosis and monitoring of proliferation and development of angiogenic tumors. Therefore, in this review, we have focused on the radioligands with VEGF121 for angiogenesis of tumor.
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